Guidelines for the Use of Ampicillin Recommended Neonatal Dose, Route, and Interval 50 mg/kg/dose by IV over 30 minutes Meningitic doses: 100 mg/kg/dose Preparing and Giving Oral Amoxicillin Sick young babies are best cared for in a hospital. When referral is not possible though, oral amoxicillin plus IM gentamicin are an effective alternative. For most infections in adults the dose of amoxicillin is 250 mg every 8 hours, 500 mg every 8 hours, 500 mg every 12 hours or 875 mg every 12 hours, depending on the type and severity of infection. For the treatment of adults with gonorrhea , the dose is 3 g given as one dose. Detectable serum levels are observed up to 8 hours after an orally administered dose of Amoxicillin. Following a 1 gram dose and utilizing a special skin window technique to determine levels of the antibiotic, it was noted that therapeutic levels were found in the interstitial fluid. -Fluoroquinolones or amoxicillin are considered the drugs of choice. Usual Adult Dose for Prevention of Perinatal Group B Streptococcal Disease (Not approved by FDA) Management of Amoxicillin Administration. Description. White to cream powder which, on reconstitution, may be red initially turning rapidly to a clear, pale yellow colour. Newborn Amoxicillin Dose - 𝖦𝖾𝗇𝖾𝗋𝗂𝖼 𝗉𝗂𝗅𝗅𝗌 𝗂𝗌 𝗎𝗌𝖾𝖽 𝗐𝗁𝖾𝗇 𝗍𝗋𝖾𝖺𝗍𝗂𝗇𝗀. Amoxicillin pharmacokinetics in preterm infants with gestational ages of less than 32 weeks. J J Huisman-de Boer , J N van den Anker , M Vogel , W H Goessens , R C Schoemaker , and R de Groot Department of Pediatrics, Erasmus University, Rotterdam, The Netherlands. Intravenous Dose: 30mg/kg/dose (N.B the dose is based on TOTAL drug not the amoxicillin component) Amoxicillin (Amoxycillin) Newborn Use Only 2017 Neonatal Medicines Formulary Consensus Group Amoxicillin (Amoxycillin) Page 1 of 4.